Most of the capuses in this region are not in downtown, none of the Texas campuses are. The Dallas one is near Northpark Mall, Houston has two, on on Loop 610 West and the other out in far north Houston and the Austin campus is actually in Round Rock (far north Austin). The Kansas City campus is in Overland Park, Denver's is in the Capitol Hill area which is pretty close to downtown. Most are in nondescript office buildings like UoP.

I think the Film Exchange area would be good location for any of those campuses, something more akin to the SCAD model than the suburban office model of many of these type of schools.

In architecture/interiors I wish there were more practiced based curriculum options like The Boston Architectural College, the only option that I found similar was the NewSchool of Architecture and Design in San Diego. The BAC is in the Back Bay area which is decidedly urban, not being familiar with San Diego but judging from the map it looks to be in the downtown area.